研究業績

Research Achievements

論文

  1. Lee K, Umemoto S, Bae J, Fujimura Y, Tachibana H. Dietary procyanidin C1 improves cognitive function through microRNA-181a-5p. J. Agric. Food Chem. in press (2026).
  2. Morita S, Machida K, Yamasaki Y, Sato M, Oshikawa H, Oshima T, Ogawa K, Nishiyama K, Tachibana H, and Yamasaki M. Broccoli-derived nanovesicles inhibited LPS-induced inflammatory response in mouse macrophage RAW264 cells. Biosci. Biotechnol. Biochem., 90, 561-570, (2026)
  3. Lee K, Otsuka Y, Kumazoe M, Fujimura Y, Tachibana H. Dietary Theogallin Enhances Cognitive Function and Neuronal Activation via Immediate-Early Gene Activation in Aged Mice. J. Agric. Food Chem. 74, 604-614, (2026).
  4. Kumazoe M, Tomioka R, Murata K, Nishioka S, Goto M, Kobarai H, Yoshitomi R, Marugame Y, Iwasaki T, Takaki K, Fujimura Y, Tachibana H. Myeloid Cell-Specific Knockout of 67-kDa Laminin Receptor Abolishes the Antifibrotic and Antiobesity Effects of Green Tea Polyphenol EGCG. J. Agric. Food Chem. 74, 2111-2123, (2026).
  5. Murata M, Nakayama K, Kitamura R, Goto M, Morozumi M, Yoshimoto T, Marugame Y, Yoshitomi R, Yamashita S, Fujimura Y, Tachibana H. Dietary rice, wheat, and soybean modulate the expression of food factor sensing-related genes in mice. International J. Food Sci. Technol. 60(2), vvaf201, (2025)
  6. Yamamoto M, Fujimura Y, Chiba R, Shimizu M, Kumazoe M, Haseda A, Nishihira J, Maeda-Yamamoto M, Tachibana H. The consumption of onion extract tablet modulates expression of human plasma microRNAs: a randomized placebo-controlled clinical trial. Sci. Rep. 15, 39710, (2025).
  7. Murata M, Marugame Y, Yamada S, Lin IC, Yamashita S, Kumazoe M, Fujimura Y, Tachibana H. Delphinidin upregulates microRNA-let-7b expression through family with sequence similarity 222 member B. Sci. Rep. 15, 29304, (2025).
  8. Marugame Y, Yoshitomi R, Lin-Yun Yang, Ting-An Lin, Lee K, Kumazoe M, Fujimura Y and Tachibana H. Regulatory effect of oolonghomobisflavan B on the expression of miRNAs secreted by intestinal cells. ACS Food Sci. Technol., 5, 3047-3053 (2025)
  9. Kumazoe M, Nakajima M, Kawamoto R, Fujimura Y, Tomioka R, Suzuki M, Tanaka Y, Tachibana H. Metabolite derived from green tea polyphenol increases and activates plasmacytoid dendritic cells. J. Nat. Med. 79(5),1057-1066, (2025).
  10. Huang YL, Morikawa-Ichinose T, Lee SU, Tatsumi Y, Ichitani M, Kumazoe M, Tachibana H, Fujimura Y. Comprehensive microRNA analysis toward exploring a new functional component in Matcha green tea. Food Chem. 10, 100265, (2025).
  11. Yoon W, Min H, Cho H, Kim H, Park W, Kim D, Tachibana H, Seo K. Bioactivity Evaluation and Phytochemical Characterization of Euonymus alatus (Thunb.) Siebold Leaf Extract. Biomedicines 12, 2928 (2024)
  12. Murata M, Takahashi R, Marugame Y, Fujimura Y, and Tachibana H. Delphinidin induces a fast-to-slow muscle fiber type shift through the AMPK signaling pathway in C2C12 myotubes. Biochem. Biophys. Rep., 40, 101884 (2024).
  13. Lu Z, Verginadis I, Kumazoe M, Castillo GM, Yao Y, Guerra RE, Bicher S, You M, McClung G, Qiu R, Xiao Z, Miao Z, George SS, Beiting DP, Nojiri T, Tanaka Y, Fujimura Y, Onda H, Hatakeyama Y, Nishimoto-Ashfield A, Bykova K, Guo W, Fan Y, Buynov NM, Diehl JA, Stanger BZ, Tachibana H, Gade TP, Puré E, Koumenis C, Bolotin EM, Fuchs SY. Modified C-type natriuretic peptide normalizes tumor vasculature, reinvigorates antitumor immunity, and improves solid tumor therapies. Science Translational Medicine. 16(761), eadn0904 (2024).
  14. Kumazoe M, Fujimura Y, Shimada Y, Onda H, Hatakeyama Y, Tachibana H. Fustin suppressed melanoma cell growth via cAMP/PKA-dependent mechanism. Biosci. Biotechnol. Biochem. 88, 900-907, (2024).
  15. Yoshitomi R, Kumazoe M, Lee KW, Marugame Y, Fujimura Y, Tachibana H. Regulatory effect of Epigallocatechin-3-O-gallate on circular RNA expression in mouse liver. J. Nutr. Biochem. 124, 109506, (2024).
  16. Kumazoe M, Miyamoto E, Oka C, Kondo M, Yoshitomi R, Onda H, Shimada Y, Fujimura Y, Tachibana H. miR-12135 ameliorates liver fibrosis accompanied with the downregulation of integrin subunit alpha 11. iScience. 27, 108730, (2024).
  17. Shimada Y, Kumazoe M, Otsuka Y, Tetsuzen R, Fujimura Y, Tachibana H. Neuroprotective effect of isovaleraldehyde accompanied with upregulation of BDNF and CREB phosphorylation via the PKA pathway. J. Nat. Med. 78, 208-215, (2024).
  18. Lim H, Bae J, Bak S, Chandimali N, Park E, Park S, Tachibana H, Won Y, and Lee S. Limocitrin Suppresses Breast Cancer Through Inducing Apoptotic-Cell Death Signaling and Inhibiting the PI3K/AKT/mTOR/S6K Cell Survival Signaling. J. Medicinal Food, 26, 749-759 (2023).
  19. Kumazoe M, Ogawa F, Hikida A, Shimada Y, Yoshitomi R, Watanabe R, Onda H, Fujimura Y, Tachibana H. Plant miRNA osa-miR172d-5p suppressed lung fibrosis by targeting Tab1. Sci. Rep. 13, 2128, (2023).
  20. Liu Z, Fukagawa Y, Yamano M, Tago T, Iwai K, Hirano K, Kumazoe M, Tachibana H, Toyohara J, and Tanaka H. A gold-complex initiated functionalization of biologically active polyphenols applied to a 18F-labeled chemical probe. Org. Biomol. Chem. 21, 5990-5996, (2023).
  21. Bae J, Kumazoe M, Lee KW, Fujimura Y, Tachibana H. 67-kDa laminin receptor mediates oolonghomobisflavan B-induced cell growth inhibition in melanoma. Phytomedicine. 118, 154970, (2023).
  22. Bae J, Kumazoe M, Park SJ, Fujimura Y, Tachibana H. The anti-cancer effect of epigallocatechin-3-O-gallate against multiple myeloma cells is potentiated by 5,7-dimethoxyflavone. FEBS Open Bio. 13, 2147-2156, (2023).
  23. Yamashita M, Kumazoe M (Equal contribution), Onda H, Hiroi S, Shimada Y, Fujimura Y, Tachibana H. PPAR/PDK4 pathway is involved in the anticancer effects of cGMP in pancreatic cancer. Biochem. Biophys. Res. Commun. 672, 154-160, (2023).
  24. Lee K, Kumazoe M, Marugame Y, Fujimura Y, Tachibana H. Dextran sulfate sodium-induced mild chronic colitis induced cognitive impairment accompanied by inhibition of neuronal maturation in adolescent mice. Biochem. Biophys. Res. Commun. 669, 46-53, (2023).
  25. Murata M, Komatsu S, Miyamoto E, Oka C, Lin I, Kumazoe M, Yamashita S, Fujimura Y, Tachibana H. Quercetin up-regulates the expression of tumor-suppressive microRNAs in human cervical cancer. Biosci. Microbiota. Food Health. 42, 87-93, (2023).
  26. Fujimura Y, Yoshimoto T, Fujino K, Nezu A, Marugame Y, Bae J, Kumazoe M, Tachibana H. Bioactivity-boosting strategy based on combination of anti-allergic O-methylated catechin with a Citrus flavanone, hesperetin. J. Nat. Med. 77, 363-369, (2023).
  27. Murata M, Marugame Y, Morozumi M, Murata K, Kumazoe M, Fujimura Y, Tachibana H. (-)-Epigallocatechin-3-O-gallate upregulates the expression levels of miR-6757-3p, a suppressor of fibrosis-related gene expression, in extracellular vesicles derived from human umbilical vein endothelial cells. Biomed. Rep. 18, 19, (2023).
  28. Shimada Y, Sato Y, Kumazoe M, Kitamura R, Fujimura Y, Tachibana H. Myricetin improves cognitive function in SAMP8 mice and upregulates brain-derived neurotrophic factor and nerve growth factor. Biochem. Biophys. Res. Commun. 616, 33-40, (2022).
  29. Fujimura Y, Watanabe M, Morikawa-Ichinose T, Fujino K, Yamamoto M, Nishioka S, Inoue C, Ogawa F, Yonekura M, Nakasone A, Kumazoe M, Tachibana H. Metabolic Profiling for Evaluating the Dipeptidyl Peptidase-IV Inhibitory Potency of Diverse Green Tea Cultivars and Determining Bioactivity-Related Ingredients and Combinations. J. Agric. Food Chem. 70, 6455-6466, (2022).
  30. Bae J, Lee K, Park J, Jung J, Tachibana H, Fujimura Y, Kumazoe M, Sung J, Cho Y, Lee S, Park S. Phosphodiesterase 5 Inhibitor Potentiates Epigallocatechin 3-O-Gallate-Induced Apoptotic Cell Death via Activation of the cGMP Signaling Pathway in Caco-2 Cells. Curr. Issues Mol. Biol. 44, 6247-6256, (2022).
  31. Morikawa-Ichinose T, Fujimura Y, Kumazoe M, Onda H, Miura D, Tachibana H. Inflammatory markers S100A8/A9 and metabolic alteration for evaluating signs of early phase toxicity of anticancer agent treatment. Food Chem. Toxicol. 169, 113421, (2022).
  32. Murata M, Marugame Y, Yamada S, Lin I, Yamashita S, Fujimura Y, Tachibana H. Circulating miRNA profiles in mice plasma following flavonoid intake. Mol. Biol. Rep., 49, 10399-10407 (2022).
  33. Hayashi D, Mouchlis V, Okamoto S, Wang L, Li S, Ueda S, Yamanoue M, Tachibana H, Arai H, Ashida H, Dennis E, and Shirai Y. Vitamin E Functions by Association with a Novel Binding Site on the 67 kDa Laminin Receptor Activating Diacylglycerol Kinase. J. Nutr. Biochem., 110, 109129 (2022).
  34. Marugame Y, Takeshita N, Yamada S, Yoshitomi R, Kumazoe M, Fujimura Y, Tachibana H. Sesame lignans upregulate glutathione S-transferase expression and downregulate microRNA-669c-3p. Biosci. Microbiota. Food Health. 41, 66-72, (2022).
  35. Kumazoe M, Fujimura Y, Yoshitomi R, Shimada Y, Tachibana H. Fustin, a Flavanonol, Synergically Potentiates the Anticancer Effect of Green Tea Catechin Epigallocatechin-3-O-Gallate with Activation of the eNOS/cGMP Axis. J. Agric. Food Chem. 70, 3458-3466, (2022).
  36. Murata M, Nakayama K, Kitamura R, Goto M, Morozumi M, Yoshimoto T, Marugame Y, Yoshitomi R, Yamashita S, Fujimura Y, and Tachibana H. Japanese soup stocks (katsuo-dashi and kombu-dashi) modulate food factor sensing-related gene expression in mice. Int. J. Gastronomy Food Sci., 29, 100573, (2022).
  37. Yamashita S, Lin I, Oka C, Kumazoe M, Komatsu S, Murata M, Kamachi S, Tachibana H. Soy isoflavone metabolite equol inhibits cancer cell proliferation in a PAP associated domain containing 5-dependent and an estrogen receptor-independent manner. J. Nutr. Biochem. 100, 108910. (2022).
  38. Kumazoe M, Takamatsu K, Horie F, Yoshitomi R, Hamagami H, Tanaka H, Fujimura Y, Tachibana H. Methylated (−)-epigallocatechin 3-O-gallate potentiates the effect of split vaccine accompanied with upregulation of Toll-like receptor 5. Sci. Rep. 11, 23101, (2021).
  39. Yoshitomi R, Yamamoto M, Kumazoe M, Fujimura Y, Yonekura M, Shimamoto Y, Nakasone A, Kondo S, Hattori H, Haseda A, Nishihira J, Tachibana H. The combined effect of green tea and α-glucosyl hesperidin in preventing obesity: a randomized placebo-controlled clinical trial. Sci. Rep. 11, 19067, (2021).
  40. Iwamoto A, Inoue Y, Tachibana H, Kawahara H. Immunomodulatory effect of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) in allergic conditions in vitro and in vivo. Cytotechnology, 73, 333-342, (2021).
  41. Kumazoe M, Tanaka Y, Yoshitomi R, Marugame Y, Lee KW, Onda H, Fujimura Y, Yonekura M, Shimamoto Y, Tachibana H. Glucosyl-hesperidin enhances the cyclic guanosine monophosphate-inducing effect of a green tea polyphenol EGCG. J. Nat. Med. 75, 1037-1042, (2021).
  42. Fujimura Y, Fujino K, Yoshimoto T, Nezu A, Marugame Y, Bae J, Kumazoe M, Tachibana H. Eriodictyol-Amplified 67-kDa Laminin Receptor Signaling Potentiates the Antiallergic Effect of O-Methylated Catechin. J. Nat. Prod. 84, 1823-1830, (2021).
  43. Tanaka Y, Kumazoe M, Onda H, Fujimura Y, Tachibana H. Time-dependent increase of plasma cGMP concentration followed by oral EGCG administration in mice. Food Bioscience. 41, 101017. (2021).
  44. Yoshitomi R, Nakayama K, Yamashita S, Kumazoe M, Lin TA, Mei CY, Marugame Y, Fujimura Y, Maeda-Yamamoto M, Kuriyama S, Tachibana H. Plasma Homocysteine Concentration is Associated with the Expression Level of Folate Receptor 3. Sci. Rep. 10, 10283, (2020).
  45. Murata M, Shimizu Y, Marugame Y, Nezu A, Fujino K, Yamada S, Kumazoe M, Fujimura Y, Tachibana H. EGCG down-regulates MuRF1 expression through 67-kDa laminin receptor and the receptor signaling is amplified by eriodictyol. J. Nat. Med. 74, 673-679, (2020).
  46. Kumazoe M, Kadomatsu M, Bae J, Otsuka Y, Fujimura Y, Tachibana H. Src Mediates Epigallocatechin-3-O-Gallate-Elicited Acid Sphingomyelinase Activation. Molecules. 25, 5481, (2020).
  47. Kumazoe M, Hiroi S, Tanimoto Y, Miyakawa J, Yamanouchi M, Suemasu Y, Yoshitomi R, Murata M, Fujimura Y, Takahashi T, Tanaka H, Tachibana H. Cancer cell selective probe by mimicking EGCG. Biochem. Biophys. Res. Commun. 525, 974-981, (2020).
  48. Bae J, Kumazoe M, Murata K, Fujimura Y, Tachibana H. Procyanidin C1 Inhibits Melanoma Cell Growth by Activating 67-kDa Laminin Receptor Signaling. Mol. Nutr. Food Res. 64, e1900986, (2020).